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Lookup NU author(s): Dr Thomas NichollsORCiD
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Cells contain thousands of copies of the mitochondrial genome. These genomes are distributed within the tubular mitochondrial network, which is itself spread across the cytosol of the cell. Mitochondrial DNA (mtDNA) replication occurs throughout the cell cycle and ensures that cells maintain a sufficient number of mtDNA copies. At replication termination the genomes must be resolved and segregated within the mitochondrial network. Defects in mtDNA replication and segregation are a cause of human mitochondrial disease associated with failure of cellular energy production. This review focuses upon recent developments on how mitochondrial genomes are physically separated at the end of DNA replication, and how these genomes are subsequently segregated and distributed around the mitochondrial network.
Author(s): Nicholls TJ, Gustafsson CM
Publication type: Review
Publication status: Published
Journal: Trends in Biochemical Sciences
Print publication date: 01/11/2018
Online publication date: 14/09/2018
Acceptance date: 01/09/2018
ISSN (print): 0968-0004
ISSN (electronic): 1362-4326
PubMed id: 30224181