Publications by Dr Thomas Nicholls - ePrints

Browsing publications by Dr Thomas Nicholls.

Newcastle Authors	Title	Year
Dr Tiago Gomes Bernardino Gomes Dr Amy Vincent Dr Katja Menger Dr Jim Stewart Dr Thomas Nicholls et al.	Mechanisms and pathologies of human mitochondrial DNA replication and deletion formation	2024
Dr Mahmoud Fassad Dr Katja Menger Sila Hopton Gavin Falkous Professor Bobby McFarland et al.	Pathological variants in TOP3A cause distinct disorders of mitochondrial and nuclear genome stability	2023
Dr Thomas Nicholls	Mammalian RNase H1 directs RNA primer formation for mtDNA replication initiation and is also necessary for mtDNA replication completion	2022
Dr Katja Menger Dr Thomas Nicholls Professor Patrick Chinnery	The human mitochondrial genome contains a second light strand promoter	2022
Dr Katja Menger Dr James Chapman Mushtaq Khazeem Dr Dasha Deen John Casement et al.	Two type I topoisomerases maintain DNA topology in human mitochondria	2022
Dr Katja Menger Alejandro Rodriguez Luis Dr James Chapman Dr Thomas Nicholls	Controlling the topology of mammalianmitochondrial DNA	2021
Dr Thomas Nicholls	The mitochondrial single-stranded DNA binding protein is essential for initiation of mtDNA replication	2021
Dr Thomas Nicholls	Recurrent Horizontal Transfer Identifies Mitochondrial Positive Selection in a Transmissible Cancer	2020
Dr James Chapman Dr Yi Ng Dr Thomas Nicholls	The Maintenance of Mitochondrial DNA Integrity and Dynamics by Mitochondrial Membranes.	2020
Dr Thomas Nicholls	Dinucleotide degradation by REXO2 maintains promoter specificity in mammalian mitochondria	2019
Dr Thomas Nicholls Professor Patrick Chinnery	Mitochondrially-targeted APOBEC1 is a potent mtDNA mutator affecting mitochondrial function and organismal fitness in Drosophila	2019
Dr Diana Lehmann Dr Helen Tuppen Georgia Campbell Charlotte Alston Dr Conor Lawless et al.	Understanding mitochondrial DNA maintenance disorders at the single muscle fibre level	2019
Dr Thomas Nicholls Dr Jim Stewart	Mice lacking the mitochondrial exonuclease MGME1 accumulate mtDNA deletions without developing progeria	2018
Dr Thomas Nicholls	Separating and Segregating the Human Mitochondrial Genome	2018
Dr Thomas Nicholls Dr Ewen Sommerville Professor Grainne Gorman Emeritus Professor Doug Turnbull Professor Patrick Chinnery et al.	Topoisomerase 3α Is Required for Decatenation and Segregation of Human mtDNA	2018
Dr Thomas Nicholls	MGME1 processes flaps into ligatable nicks in concert with DNA polymerase γ during mtDNA replication	2016
Dr Thomas Nicholls	Mitochondrial transcript maturation and its disorders	2015
Dr Thomas Nicholls	Nuclear-encoded factors involved in post-transcriptional processing and modification of mitochondrial tRNAs in human disease	2015
Dr Thomas Nicholls	In D-loop: 40 years of mitochondrial 7S DNA	2014
Dr Thomas Nicholls	Linear mtDNA fragments and unusual mtDNA rearrangements associated with pathological deficiency of MGME1 exonuclease	2014
Dr Joanna Rorbach Dr Pierre Boesch Dr Thomas Nicholls	MRM2 and MRM3 are involved in biogenesis of the large subunit of the mitochondrial ribosome	2014