Lookup NU author(s): Dr Simon Wilkinson
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© 2019 Royal Pharmaceutical SocietyObjectives: The aim of this study was to use Gaussian process regression (GPR) methods to quantify the effect of experimental temperature (Texp) and choice of diffusion cell on model quality and performance. Methods: Data were collated from the literature. Static and flow-through diffusion cell data were separated, and a series of GPR experiments was conducted. The effect of Texp was assessed by comparing a range of datasets where Texp either remained constant or was varied from 22 to 45 °C. Key findings: Using data from flow-through diffusion cells results in poor model performance. Data from static diffusion cells resulted in significantly greater performance. Inclusion of data from flow-through cell experiments reduces overall model quality. Consideration of Texp improves model quality when the dataset used exhibits a wide range of experimental temperatures. Conclusions: This study highlights the problem of collating literature data into datasets from which models are constructed without consideration of the nature of those data. In order to optimise model quality data from only static, Franz-type, experiments should be used to construct the model and Texp should either be incorporated as a descriptor in the model if data are collated from a range of studies conducted at different temperatures.
Author(s): Ashrafi P, Sun Y, Davey N, Wilkinson SC, Moss GP
Publication type: Article
Publication status: Published
Journal: Journal of Pharmacy and Pharmacology
Issue: ePub ahead of Print
Online publication date: 14/11/2019
Acceptance date: 26/10/2019
ISSN (print): 0022-3573
ISSN (electronic): 2042-7158
Publisher: Blackwell Publishing Ltd
PubMed id: 31724749
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