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Are genetic and idiopathic forms of Parkinson's disease the same disease?

Lookup NU author(s): Professor Tiago OuteiroORCiD


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© 2019 International Society for NeurochemistryGenetic forms represent a small fraction of Parkinson's disease (PD) but their discovery has revolutionized research in the field, putting α-synuclein in the spotlight, and uncovering other key neuropathological mechanisms of the disease. The question of whether genetic and idiopathic PD (iPD) correspond to a same disease entity is not simply philosophical, has implications for the discovery of the biological background of PD and for the development of novel therapeutic strategies that may also be applicable to the larger iPD group. Here, we review the current landscape of what has been labeled genetic PD and critically discuss the rational for merging or separating genetic and idiopathic forms of PD as the same or different disease entities. We conclude by addressing the potential implications for future research. (Figure presented.).

Publication metadata

Author(s): Correia Guedes L, Mestre T, Outeiro TF, Ferreira JJ

Publication type: Review

Publication status: Published

Journal: Journal of Neurochemistry

Year: 2020

Volume: 152

Issue: 5

Pages: 515-522

Print publication date: 27/02/2020

Online publication date: 23/10/2019

Acceptance date: 16/10/2019

ISSN (print): 0022-3042

ISSN (electronic): 1471-4159

Publisher: Blackwell Publishing Ltd


DOI: 10.1111/jnc.14902

PubMed id: 31643079