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Lookup NU author(s): Professor Tiago OuteiroORCiD
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© 2019 International Society for NeurochemistryGenetic forms represent a small fraction of Parkinson's disease (PD) but their discovery has revolutionized research in the field, putting α-synuclein in the spotlight, and uncovering other key neuropathological mechanisms of the disease. The question of whether genetic and idiopathic PD (iPD) correspond to a same disease entity is not simply philosophical, has implications for the discovery of the biological background of PD and for the development of novel therapeutic strategies that may also be applicable to the larger iPD group. Here, we review the current landscape of what has been labeled genetic PD and critically discuss the rational for merging or separating genetic and idiopathic forms of PD as the same or different disease entities. We conclude by addressing the potential implications for future research. (Figure presented.).
Author(s): Correia Guedes L, Mestre T, Outeiro TF, Ferreira JJ
Publication type: Review
Publication status: Published
Journal: Journal of Neurochemistry
Print publication date: 27/02/2020
Online publication date: 23/10/2019
Acceptance date: 16/10/2019
ISSN (print): 0022-3042
ISSN (electronic): 1471-4159
Publisher: Blackwell Publishing Ltd
PubMed id: 31643079