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The effects of vitamin C and E on exercise-induced physiological adaptations: a systematic review and Meta-analysis of randomized controlled trials

Lookup NU author(s): Tom Clifford, Dr Owen JeffriesORCiD, Professor Emma Stevenson, Dr Kelly Bowden DaviesORCiD

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This is the authors' accepted manuscript of an article that has been published in its final definitive form by Taylor & Francis Inc. , 2020.

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Abstract

We conducted a systematic review and meta-analysis of randomized controlled trials examining the effect of vitamin C and/or E on exercise-induced training adaptations. Medline, Embase and SPORTDiscus databases were searched for articles from inception until June 2019. Inclusion criteria was studies in adult humans where vitamin C and/or E had to be consumed alongside a supervised exercise training program of ≥4 weeks. Nine trials were included in the analysis of aerobic exercise adaptations and nine for resistance training (RT) adaptations. Vitamin C and/or E did not attenuate aerobic exercise induced improvements in maximal aerobic capacity ([Formula: see text]O2max) (SMD -0.14, 95% CI: -0.43 to 0.15, P = 0.35) or endurance performance (SMD -0.01, 95% CI: -0.38 to 0.36, P = 0.97). There were also no effects of these supplements on lean mass and muscle strength following RT (SMD -0.07, 95% CI: -0.36 to 0.23, P = 0.67) and (SMD -0.15, 95% CI: -0.16 to 0.46, P = 0.35), respectively. There was also no influence of age on any of these outcomes (P > 0.05). These findings suggest that vitamin C and/or E does not inhibit exercise-induced changes in physiological function. Studies with larger sample sizes and adequate power are still required.


Publication metadata

Author(s): Clifford T, Jeffries O, Stevenson EJ, Bowden Davies KA

Publication type: Article

Publication status: Published

Journal: Critical Reviews in Food Science and Nutrition

Year: 2020

Volume: 60

Issue: 21

Pages: 3669-3679

Online publication date: 18/12/2019

Acceptance date: 09/12/2019

Date deposited: 08/01/2020

ISSN (print): 1040-8398

ISSN (electronic): 1549-7852

Publisher: Taylor & Francis Inc.

URL: https://doi.org/10.1080/10408398.2019.1703642

DOI: 10.1080/10408398.2019.1703642

PubMed id: 31851538


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