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Lookup NU author(s): Dr Alexander Sieberath, Dr Ana Ferreira-DuarteORCiD, Dr Piergiorgio GentileORCiD, Professor Kenneth Dalgarno
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
As the population of western societies on average ages, the number of people affected by bone remodeling-associated diseases such as osteoporosis continues to increase. The development of new therapeutics is hampered by the high failure rates of drug candidates during clinical testing, which is in part due to the poor predictive character of animal models during preclinical drug testing. Co-culture models of osteoblasts and osteoclasts offer an alternative to animal testing and are considered to have the potential to improve drug development processes in the future. However, a robust, scalable, and reproducible 3D model combining osteoblasts and osteoclasts for preclinical drug testing purposes has not been developed to date. Here we review various types of osteoblast-osteoclast co-culture models and outline the remaining obstacles that must be overcome for their successful translation.
Author(s): Sieberath A, Della Bella E, Ferreira AM, Gentile P, Eglin D, Dalgarno K
Publication type: Review
Publication status: Published
Journal: International Journal of Molecular Sciences
Year: 2020
Volume: 21
Issue: 3
Online publication date: 30/01/2020
Acceptance date: 21/01/2020
ISSN (print): 1661-6596
ISSN (electronic): 1422-0067
Publisher: NLM (Medline)
URL: https://doi.org/10.3390/ijms21030912
DOI: 10.3390/ijms21030912
PubMed id: 32019244
