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Engineering Prostate Cancer from Induced Pluripotent Stem Cells-New Opportunities to Develop Preclinical Tools in Prostate and Prostate Cancer Studies

Lookup NU author(s): Dr Anastasia Hepburn, Dr Cole SimsORCiD, Dr Adriana BuskinORCiD, Professor Rakesh Heer

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Abstract

One of the key issues hampering the development of effective treatments for prostate cancer is the lack of suitable, tractable, and patient-specific in vitro models that accurately recapitulate this disease. In this review, we address the challenges of using primary cultures and patient-derived xenografts to study prostate cancer. We describe emerging approaches using primary prostate epithelial cells and prostate organoids and their genetic manipulation for disease modelling. Furthermore, the use of human prostate-derived induced pluripotent stem cells (iPSCs) is highlighted as a promising complimentary approach. Finally, we discuss the manipulation of iPSCs to generate 'avatars' for drug disease testing. Specifically, we describe how a conceptual advance through the creation of living biobanks of "genetically engineered cancers" that contain patient-specific driver mutations hold promise for personalised medicine.

Publication metadata

Author(s): Hepburn AC, Sims CHC, Buskin A, Heer R

Publication type: Review

Publication status: Published

Journal: International Journal of Molecular Sciences

Year: 2020

Volume: 21

Issue: 3

Online publication date: 30/01/2020

Acceptance date: 28/01/2020

ISSN (print): 1661-6596

ISSN (electronic): 1422-0067

Publisher: NLM (Medline)

URL: https://doi.org/10.3390/ijms21030905

DOI: 10.3390/ijms21030905

PubMed id: 32019175

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