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Plastic Circuits: Regulatory Flexibility in Fine Tuning Pathogen Success

Lookup NU author(s): James ConnollyORCiD


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© 2020 The Authors. Bacterial pathogens employ diverse fitness and virulence mechanisms to gain an advantage in competitive niches. These lifestyle-specific traits require integration into the regulatory network of the cell and are often controlled by pre-existing transcription factors. In this review, we highlight recent advances that have been made in characterizing this regulatory flexibility in prominent members of the Enterobacteriaceae. We focus on the direct global interactions between transcription factors and their target genes in pathogenic Escherichia coli and Salmonella revealed using chromatin immunoprecipitation coupled with next-generation sequencing. Furthermore, the implications and advantages of such regulatory adaptations in benefiting distinct pathogenic lifestyles are discussed.

Publication metadata

Author(s): O'Boyle N, Turner NCA, Roe AJ, Connolly JPR

Publication type: Review

Publication status: Published

Journal: Trends in Microbiology

Year: 2020

Volume: 28

Issue: 5

Pages: 360-371

Print publication date: 01/05/2020

Online publication date: 11/02/2020

Acceptance date: 16/01/2020

ISSN (print): 0966-842X

ISSN (electronic): 1878-4380

Publisher: Elsevier Ltd


DOI: 10.1016/j.tim.2020.01.002