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Lookup NU author(s): James Connolly
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© 2020 The Authors. Bacterial pathogens employ diverse fitness and virulence mechanisms to gain an advantage in competitive niches. These lifestyle-specific traits require integration into the regulatory network of the cell and are often controlled by pre-existing transcription factors. In this review, we highlight recent advances that have been made in characterizing this regulatory flexibility in prominent members of the Enterobacteriaceae. We focus on the direct global interactions between transcription factors and their target genes in pathogenic Escherichia coli and Salmonella revealed using chromatin immunoprecipitation coupled with next-generation sequencing. Furthermore, the implications and advantages of such regulatory adaptations in benefiting distinct pathogenic lifestyles are discussed.
Author(s): O'Boyle N, Turner NCA, Roe AJ, Connolly JPR
Publication type: Review
Publication status: Published
Journal: Trends in Microbiology
Print publication date: 01/05/2020
Online publication date: 11/02/2020
Acceptance date: 16/01/2020
ISSN (print): 0966-842X
ISSN (electronic): 1878-4380
Publisher: Elsevier Ltd