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The Alzheimer's Disease Amyloid-Beta Hypothesis in Cardiovascular Aging and Disease: JACC Focus Seminar

Lookup NU author(s): Professor Kimon Stamatelopoulos, Lefteris Zormpas, Dr Nikolaos VlachogiannisORCiD, Dr Simon Tual-Chalot, Professor Konstantinos StellosORCiD



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


© 2020 The AuthorsAging-related cellular and molecular processes including low-grade inflammation are major players in the pathogenesis of cardiovascular disease (CVD) and Alzheimer's disease (AD). Epidemiological studies report an independent interaction between the development of dementia and the incidence of CVD in several populations, suggesting the presence of overlapping molecular mechanisms. Accumulating experimental and clinical evidence suggests that amyloid-beta (Aβ) peptides may function as a link among aging, CVD, and AD. Aging-related vascular and cardiac deposition of Αβ induces tissue inflammation and organ dysfunction, both important components of the Alzheimer's disease amyloid hypothesis. In this review, the authors describe the determinants of Aβ metabolism, summarize the effects of Aβ on atherothrombosis and cardiac dysfunction, discuss the clinical value of Αβ1-40 in CVD prognosis and patient risk stratification, and present the therapeutic interventions that may alter Aβ metabolism in humans.

Publication metadata

Author(s): Stakos DA, Stamatelopoulos K, Bampatsias D, Sachse M, Zormpas E, Vlachogiannis NI, Tual-Chalot S, Stellos K

Publication type: Review

Publication status: Published

Journal: Journal of the American College of Cardiology

Year: 2020

Volume: 75

Issue: 8

Pages: 952-967

Print publication date: 03/03/2020

Online publication date: 24/02/2020

Acceptance date: 03/12/2019

ISSN (print): 0735-1097

ISSN (electronic): 1558-3597

Publisher: Elsevier USA


DOI: 10.1016/j.jacc.2019.12.033