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Telomeres: beacons of autocrine and paracrine DNA damage during skin aging

Lookup NU author(s): Stella Victorelli, Dr Joao Passos

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Abstract

© 2020, © 2020 Informa UK Limited, trading as Taylor & Francis Group.Cellular senescence is an irreversible cell cycle arrest, which can be triggered by a number of stressors, including telomere damage. Among many other phenotypic changes, senescence is accompanied by increased secretion of pro-inflammatory molecules, also known as the senescence-associated secretory phenotype (SASP). It is thought that accumulation of senescent cells contributes to age-associated tissue dysfunction partly by inducing senescence in neighboring cells through mechanisms involving SASP factors. Here, we will review evidence suggesting that telomeres can become dysfunctional irrespectively of shortening, and that this may be a mechanism-driving senescence in post-mitotic or slow dividing cells. Furthermore, we review recent evidence that supports that senescent melanocytes induce paracrine telomere damage during skin aging, which may be the mechanism responsible for propagation of senescent cells. We propose that telomeres are sensors of imbalances in the cellular milieu and act as beacons of stress, contributing to autocrine and paracrine senescence.

Publication metadata

Author(s): Victorelli S, Passos JF

Publication type: Review

Publication status: Published

Journal: Cell Cycle

Year: 2020

Volume: 19

Issue: 5

Pages: 532-540

Online publication date: 16/02/2020

Acceptance date: 06/02/2020

ISSN (print): 1538-4101

ISSN (electronic): 1551-4005

Publisher: Taylor and Francis Inc.

URL: https://doi.org/10.1080/15384101.2020.1728016

DOI: 10.1080/15384101.2020.1728016

PubMed id: 32065062

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