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Lung biopsy in children: when is it useful?

Lookup NU author(s): Dr Corey ChanORCiD, Bruce Jaffray, Dr Malcolm Brodlie, Hany GabraORCiD



This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).


Aim To provide a further insight into the usefulness of lung biopsy in children.Methods Lung biopsies in children from January 2007 to December 2017 were reviewed (n=39). The histology results were categorised as: definitive diagnosis, normal lung parenchyma, inconclusive.Results Lung biopsy provided a definitive diagnosis in 25 (64%) cases. A suspected diagnosis was confirmed in 16 (41%) and a new diagnosis was found in 9 (23%) children. Histology was inconclusive in 11 (28%) cases and normal in 3 (8%). Fifteen (38%) children had treatment altered due to the biopsy result.Conclusion Lung biopsy mostly confirmed the suspected diagnosis and was associated with a low procedure related morbidity (n=1) and mortality (n=0). Importantly, the biopsy result identified a pathology which altered treatment in over one third of patients. However, in a number of cases the histology was inconclusive, therefore careful patient selection is recommended to maximise diagnostic yield.

Publication metadata

Author(s): Chan CD, Nyogi A, Jaffray B, Brodlie M, Gabra H

Publication type: Article

Publication status: Published

Journal: Archives of Disease in Childhood

Year: 2021

Volume: 106

Issue: 3

Pages: 291-293

Print publication date: 01/03/2021

Online publication date: 29/04/2020

Acceptance date: 29/01/2020

Date deposited: 04/05/2020

ISSN (print): 0003-9888

ISSN (electronic): 1468-2044

Publisher: BMJ Group


DOI: 10.1136/archdischild-2019-318443

PubMed id: 32349979


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Funder referenceFunder name
Malcolm Brodlie was supported by a Medical Research Council Clinician Scientist Fellowship (MR/M008797/1).