Toggle Main Menu Toggle Search

Open Access padlockePrints

Effect of Pressure-controlled intermittent Coronary Sinus Occlusion (PiCSO) on infarct size in anterior STEMI: PiCSO in ACS study

Lookup NU author(s): Dr Mohaned Egred, Dr Alan Bagnall, Professor Ioakim SpyridopoulosORCiD, Dr Rajiv Das, Professor Azfar Zaman



This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).


© 2020 The AuthorsBackground: The aim of this clinical research was to investigate the effects of Pressure-controlled intermittent Coronary Sinus Occlusion (PiCSO) on infarct size at 5 days after primary percutaneous coronary intervention (pPCI) in patients with ST-segment elevation myocardial infarction (STEMI). Methods and results: This comparative study was carried out in four UK hospitals. Forty-five patients with anterior STEMI presenting within 12 h of symptom onset received pPCI plus PiCSO (initiated after reperfusion; n = 45) and were compared with a propensity score-matched control cohort from INFUSE-AMI (n = 80). Infarct size (% of LV mass, median [interquartile range]) measured by cardiac magnetic resonance (CMR) at day 5 was significantly lower in the PiCSO group (14.3% [95% CI 9.2–19.4%] vs. 21.2% [95% CI 18.0–24.4%]; p = 0.023). There were no major adverse cardiac events (MACE) related to the PiCSO intervention. Conclusions: PiCSO, as an adjunct to pPCI, was associated with a lower infarct size at 5 days after anterior STEMI in a propensity score-matched population.

Publication metadata

Author(s): Egred M, Bagnall A, Spyridopoulos I, Purcell IF, Das R, Palmer N, Grech ED, Jain A, Stone GW, Nijveldt R, McAndrew T, Zaman A

Publication type: Article

Publication status: Published

Journal: IJC Heart and Vasculature

Year: 2020

Volume: 28

Online publication date: 15/05/2020

Acceptance date: 17/04/2020

Date deposited: 29/05/2020

ISSN (print): 2352-9067

Publisher: Elsevier Ireland Ltd


DOI: 10.1016/j.ijcha.2020.100526


Altmetrics provided by Altmetric