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Lookup NU author(s): Professor James Shaw
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© 2020 The Authors. Diabetes, Obesity and Metabolism published by John Wiley & Sons Ltd. Insulin is routinely used to manage hyperglycaemia in organ donors and during the peri-transplant period in islet transplant recipients. However, it is unknown whether donor insulin use (DIU) predicts beta-cell dysfunction after islet transplantation. We reviewed data from the UK Transplant Registry and the UK Islet Transplant Consortium; all first-time transplants during 2008-2016 were included. Linear regression models determined associations between DIU, median and coefficient of variation (CV) peri-transplant glucose levels and 3-month islet graft function. In 91 islet cell transplant recipients, DIU was associated with lower islet function assessed by BETA-2 scores (β [SE] -3.5 [1.5], P =.02), higher 3-month post-transplant HbA1c levels (5.4 [2.6] mmol/mol, P =.04) and lower fasting C-peptide levels (−107.9 [46.1] pmol/l, P =.02). Glucose at 10 512 time points was recorded during the first 5 days peri-transplant: the median (IQR) daily glucose level was 7.9 (7.0-8.9) mmol/L and glucose CV was 28% (21%-35%). Neither median glucose levels nor glucose CV predicted outcomes post-transplantation. Data on DIU predicts beta-cell dysfunction 3 months after islet transplantation and could help improve donor selection and transplant outcomes.
Author(s): Shapey IM, Summers A, Yiannoullou P, Khambalia H, Fullwood C, Hanley NA, Casey J, Forbes S, Rosenthal M, Johnson PRV, Choudhary P, Bushnell J, Shaw JAM, Augustine T, Rutter MK, van Dellen D
Publication type: Article
Publication status: Published
Journal: Diabetes, Obesity and Metabolism
Print publication date: 01/10/2020
Online publication date: 25/05/2020
Acceptance date: 10/05/2020
ISSN (print): 1462-8902
ISSN (electronic): 1463-1326
Publisher: John Wiley & Sons Ltd
PubMed id: 32452110
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