Toggle Main Menu Toggle Search

Open Access padlockePrints

Bioprospection of natural sources of polyphenols with therapeutic potential for redox-related diseases

Lookup NU author(s): Professor Tiago OuteiroORCiD



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


© 2020 by the authors. Licensee MDPI, Basel, Switzerland.Plants are a reservoir of high-value molecules with underexplored biomedical applications. With the aim of identifying novel health-promoting attributes in underexplored natural sources, we scrutinized the diversity of (poly)phenols present within the berries of selected germplasm from cultivated, wild, and underutilized Rubus species. Our strategy combined the application of metabolomics, statistical analysis, and evaluation of (poly)phenols’ bioactivity using a yeast-based discovery platform. We identified species as sources of (poly)phenols interfering with pathological processes associated with redox-related diseases, particularly, amyotrophic lateral sclerosis, cancer, and inflammation. In silico prediction of putative bioactives suggested cyanidin–hexoside as an anti-inflammatory molecule which was validated in yeast and mammalian cells. Moreover, cellular assays revealed that the cyanidin moiety was responsible for the anti-inflammatory properties of cyanidin–hexoside. Our findings unveiled novel (poly)phenolic bioactivities and illustrated the power of our integrative approach for the identification of dietary (poly)phenols with potential biomedical applications.

Publication metadata

Author(s): Menezes R, Foito A, Jardim C, Costa I, Garcia G, Rosado-Ramos R, Freitag S, Alexander CJ, Outeiro TF, Stewart D, Santos CN

Publication type: Article

Publication status: Published

Journal: Antioxidants

Year: 2020

Volume: 9

Issue: 9

Online publication date: 26/08/2020

Acceptance date: 18/08/2020

Date deposited: 19/07/2022

ISSN (electronic): 2076-3921

Publisher: MDPI AG


DOI: 10.3390/antiox9090789


Altmetrics provided by Altmetric


Funder referenceFunder name
BacHBerry FP7-KBBE-2013-613793
EXC 2067/1-390729940
The Scottish Government Rural and Environment Science and Analytical Services Division