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The role of EEG in the diagnosis, prognosis and clinical correlations of Dementia with Lewy Bodies—a systematic review

Lookup NU author(s): Dr Zhe Kang Law, Carein Todd, Ramtin Mehraram, Julia Schumacher, Dr Mark Baker, Dr Fiona LeBeau, Dr Alison Yarnall, Professor Alan Thomas, Professor John-Paul Taylor

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Abstract

© 2020 by the authors.Despite improvements in diagnostic criteria for dementia with Lewy bodies (DLB), the ability to discriminate DLB from Alzheimer’s disease (AD) and other dementias remains suboptimal. Electroencephalography (EEG) is currently a supportive biomarker in the diagnosis of DLB. We performed a systematic review to better clarify the diagnostic and prognostic role of EEG in DLB and define the clinical correlates of various EEG features described in DLB. MEDLINE, EMBASE, and PsycINFO were searched using search strategies for relevant articles up to 6 August 2020. We included 43 studies comparing EEG in DLB with other diagnoses, 42 of them included a comparison of DLB with AD, 10 studies compared DLB with Parkinson’s disease dementia, and 6 studies compared DLB with other dementias. The studies were visual EEG assessment (6), quantitative EEG (35) and event-related potential studies (2). The most consistent observation was the slowing of the dominant EEG rhythm (<8 Hz) assessed visually or through quantitative EEG, which was observed in ~90% of patients with DLB and only ~10% of patients with AD. Other findings based on qualitative rating, spectral power analyses, connectivity, microstate and machine learning algorithms were largely heterogenous due to differences in study design, EEG acquisition, preprocessing and analysis. EEG protocols should be standardized to allow replication and validation of promising EEG features as potential biomarkers in DLB.


Publication metadata

Author(s): Law ZK, Todd C, Mehraram R, Schumacher J, Baker MR, LeBeau FEN, Yarnall A, Onofrj M, Bonanni L, Thomas A, Taylor J-P

Publication type: Review

Publication status: Published

Journal: Diagnostics

Year: 2020

Volume: 10

Issue: 9

Print publication date: 01/09/2020

Online publication date: 20/08/2020

Acceptance date: 18/08/2020

ISSN (electronic): 2075-4418

Publisher: MDPI AG

URL: https://doi.org/10.3390/diagnostics10090616

DOI: 10.3390/diagnostics10090616


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