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SARS-CoV-2, immunosenescence and inflammaging: Partners in the COVID-19 crime

Lookup NU author(s): Professor Tiago OuteiroORCiD



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


© 2020 Domingues et al.Pneumonia outbreak in the city of Wuhan, China, prompted the finding of a novel strain of severe acute respiratory syndrome virus (SARS-CoV-2). Here, we discuss potential long-term consequences of SARS-CoV-2 infection, and its possibility to cause permanent damage to the immune system and the central nervous system. Advanced chronological age is one of the main risk factors for the adverse outcomes of COVID-19, presumably due to immunosenescence and chronic low-grade inflammation, both characteristic of the elderly. The combination of viral infection and chronic inflammation in advanced chronological age might cause multiple detrimental unforeseen consequences for the predisposition and severity of neurodegenerative diseases and needs to be considered so that we can be prepared to deal with future outcomes of the ongoing pandemic.

Publication metadata

Author(s): Domingues R, Lippi A, Setz C, Outeiro TF, Krisko A

Publication type: Review

Publication status: Published

Journal: Aging

Year: 2020

Volume: 12

Issue: 18

Pages: 18778-18789

Online publication date: 29/09/2020

Acceptance date: 11/08/2020

ISSN (electronic): 1945-4589

Publisher: Impact Journals LLC


DOI: 10.18632/aging.103989