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Comment on “The Memory of the Heart”, J. Cardiovasc. Dev. Dis. 2018, 5, 55

Lookup NU author(s): Professor Bob Anderson



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


© 2018 by the author. Licensee MDPI, Basel, Switzerland.In his recent review for the Journal of Cardiovascular Development and Disease, Cirillo offers a concept for “cardiac memory” based on the notion that the ventricular cone can be unwrapped to show a myocardial band extending from the pulmonary to the aortic root. The concept of the myocardial band was itself developed by Torrent Guasp, and has subsequently been championed by Buckberg. Neither Torrent Guasp, when formulating his initial concept, nor Buckberg in his subsequent endorsements, have validated the results of dissection using histological or other techniques that would reveal the boundaries of the alleged band. In contrast, there is a wealth of evidence showing that such boundaries do not exist and that the cardiomyocytes are packed together within the walls of the ventricular cone in the form of a three-dimensional mesh. The evidence demonstrating the manner of packing of the cardiomyocytes within the ventricular walls was summarised in another recent review published in the journal. It is disappointing that Cirillo chose to ignore the wealth of evidence disproving the concept on which he bases his entire review. Only by recognising the existence of this evidence can we truly understand ventricular function correctly, as envisaged by Cirillo.

Publication metadata

Author(s): Anderson RH

Publication type: Note

Publication status: Published

Journal: Journal of Cardiovascular Development and Disease

Year: 2018

Volume: 5

Issue: 4

Print publication date: 01/12/2018

Online publication date: 19/12/2018

Acceptance date: 08/12/2018

ISSN (electronic): 2308-3425

Publisher: MDPI AG


DOI: 10.3390/jcdd5040060