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Managing cognitive symptoms and fatigue in cholestatic liver disease

Lookup NU author(s): Dr April Phaw, Dr Jess Leighton, Dr Jess Dyson, Professor David Jones


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© 2020 Informa UK Limited, trading as Taylor & Francis Group. Introduction: Patients with cholestatic diseases may develop fatigue and cognitive symptoms. The impact of symptom burden may be significant in some patients. To date, there are no effective pharmacological therapies to improve cognitive symptoms or fatigue in cholestasis and we are wholly reliant on supportive approaches. Area covered: This review provides an overview of cognitive symptoms and fatigue in the cholestatic liver disease primary biliary cholangitis (PBC), including pathophysiology and our approach to the management of these symptoms. Expert opinion: The impact of fatigue and cognitive symptoms on the perceived quality of life can be profound for patients with PBC. The pathophysiology of these symptoms is complex and poorly understood, making the development of therapeutic trials of symptom-directed therapies challenging. The current recommended management for fatigue and cognitive symptoms is mainly supportive.

Publication metadata

Author(s): Phaw NA, Leighton J, Dyson JK, Jones DE

Publication type: Review

Publication status: Published

Journal: Expert Review of Gastroenterology and Hepatology

Year: 2021

Volume: 15

Issue: 3

Pages: 235-241

Online publication date: 11/11/2020

Acceptance date: 02/11/2020

ISSN (print): 1747-4124

ISSN (electronic): 1747-4132

Publisher: Taylor and Francis Ltd.


DOI: 10.1080/17474124.2021.1844565

PubMed id: 33131347