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Successful biodegradable stent insertion in an infant with severe bronchomalacia and cystic fibrosis

Lookup NU author(s): Dr Malcolm Brodlie



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


© 2020 The Authors. We report the first case of biodegradable airway stent insertion for a patient with bronchomalacia and cystic fibrosis (CF). This female infant with antenatally diagnosed cystic fibrosis developed respiratory distress by three weeks of age. On lower airway examination she was found to have severe left main stem bronchomalacia causing left upper lobe hyperinflation and subsequent right upper lobe collapse. By eight weeks of age she developed life-threatening respiratory failure requiring high pressure invasive ventilation. A biodegradable bronchial stent was inserted to the left main bronchus at thirteen weeks of age with successful extubation from invasive respiratory support four days later. A second biodegradable stent was inserted nine weeks later, due to persistent bronchomalacia following stent degradation and redevelopment of oxygen requirement. She was discharged home off all respiratory support eight weeks later and has remained well, requiring no further surgical intervention for bronchomalacia to date, now age three years.

Publication metadata

Author(s): Harris CA, Brodlie M, O'Brien C, Thomas MF

Publication type: Article

Publication status: Published

Journal: Journal of Cystic Fibrosis

Year: 2021

Volume: 20

Issue: 2

Pages: e13-e15

Print publication date: 01/03/2021

Online publication date: 07/11/2020

Acceptance date: 23/10/2020

Date deposited: 24/05/2021

ISSN (print): 1569-1993

ISSN (electronic): 1873-5010

Publisher: Elsevier BV


DOI: 10.1016/j.jcf.2020.10.004

PubMed id: 33168477


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Funder referenceFunder name
MR/M008797/1Medical Research Council (MRC)