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Cancer prevention through weight control—where are we in 2020?

Lookup NU author(s): Professor Falko Sniehotta


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© 2020, Cancer Research UK. Growing data from epidemiological studies highlight the association between excess body fat and cancer incidence, but good indicative evidence demonstrates that intentional weight loss, as well as increasing physical activity, offers much promise as a cost-effective approach for reducing the cancer burden. However, clear gaps remain in our understanding of how changes in body fat or levels of physical activity are mechanistically linked to cancer, and the magnitude of their impact on cancer risk. It is important to investigate the causal link between programmes that successfully achieve short-term modest weight loss followed by weight-loss maintenance and cancer incidence. The longer-term impact of weight loss and duration of overweight and obesity on risk reduction also need to be fully considered in trial design. These gaps in knowledge need to be urgently addressed to expedite the development and implementation of future cancer-control strategies. Comprehensive approaches to trial design, Mendelian randomisation studies and data-linkage opportunities offer real possibilities to tackle current research gaps. In this paper, we set out the case for why non-pharmacological weight-management trials are urgently needed to support cancer-risk reduction and help control the growing global burden of cancer.

Publication metadata

Author(s): Anderson AS, Renehan AG, Saxton JM, Bell J, Cade J, Cross AJ, King A, Riboli E, Sniehotta F, Treweek S, Martin RM, Anderson A, Beeken R, Cade J, Cross A, King A, Martin R, Mitrou G, Riboli E, Saxton J, Renehan A, UK NIHR Cancer and Nutrition Collaboration (Population Health Stream)

Publication type: Review

Publication status: Published

Journal: British Journal of Cancer

Year: 2021

Volume: 124

Pages: 1049-1056

Print publication date: 16/03/2021

Online publication date: 25/11/2020

Acceptance date: 22/10/2020

ISSN (print): 0007-0920

ISSN (electronic): 1532-1827

Publisher: Springer Nature


DOI: 10.1038/s41416-020-01154-3