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Circulating Amyloid Beta 1-40 Is Associated with Increased Rate of Progression of Atherosclerosis in Menopause: A Prospective Cohort Study

Lookup NU author(s): Dr Simon Tual-Chalot, Dr Nikolaos VlachogiannisORCiD, Professor Konstantinos StellosORCiD, Professor Kimon Stamatelopoulos



This is the authors' accepted manuscript of a review that has been published in its final definitive form by Georg Thieme Verlag, 2021.

For re-use rights please refer to the publisher's terms and conditions.


© 2020 Georg Thieme Verlag. All rights reserved. Background-Accumulating evidence suggests that circulating amyloidβ 1-40 (Î'β1-40), a proatherogenic aging peptide, may serve as a novel biomarker in cardiovascular disease (CVD). We aimed to explore the role of plasma Î'β1-40 and its patterns of change over time in atherosclerosis progression in postmenopausal women, a population with substantial unrecognized CVD risk beyond traditional risk factors (TRFs). Methods âIn this prospective study, Î'β1-40 was measured in plasma by enzyme-linked immunosorbent assay and atherosclerosis was assessed using carotid high-resolution ultrasonography at baseline and after a median follow-up of 28.2 months in 152 postmenopausal women without history or symptoms of CVD. Results âAt baseline, high Î'β1-40 was independently associated with higher carotid bulb intima-media thickness (cbIMT) and the sum of maximal wall thickness in all carotid sites (sumWT) (p < 0.05). Î'β1-40 levels increased over time and were associated with decreasing renal function (p < 0.05 for both). Women with a pattern of increasing or persistently high Î'β1-40 levels presented accelerated progression of cbIMT and maximum carotid wall thickness and sumWT (p < 0.05 for all) after adjustment for baseline Î'β1-40 levels, TRFs, and renal function. Conclusion âIn postmenopausal women, a pattern of increasing or persistently high Î'β1-40 was associated with the rate of progression of subclinical atherosclerosis irrespective of its baseline levels. These findings provide novel insights into a link between Î'β1-40 and atherosclerosis progression in menopause and warrant further research to clarify the clinical value of monitoring its circulating levels as an atherosclerosis biomarker in women without clinically overt CVD.

Publication metadata

Author(s): Lambrinoudaki I, Delialis D, Georgiopoulos G, Tual-Chalot S, Vlachogiannis NI, Patras R, Aivalioti E, Armeni E, Augoulea A, Tsoltos N, Soureti A, Stellos K, Stamatelopoulos K

Publication type: Review

Publication status: Published

Journal: Thrombosis and Haemostasis

Year: 2021

Volume: 121

Issue: 05

Pages: 650-658

Print publication date: 01/05/2021

Online publication date: 17/11/2020

Acceptance date: 10/10/2020

ISSN (print): 0340-6245

ISSN (electronic): 2567-689X

Publisher: Georg Thieme Verlag


DOI: 10.1055/s-0040-1721144

PubMed id: 33202443