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Imaging Familial and Sporadic Neurodegenerative Disorders associated with Parkinsonism

Lookup NU author(s): Professor David BrooksORCiD



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


In this paper the structural and functional imaging changes associated with sporadic and genetic Parkinson’s disease and atypical Parkinsonian variants are reviewed. The role of imaging for supporting diagnosis and detecting subclinical disease is discussed and the potential use and drawbacks of using imaging biomarkers for monitoring disease progression is debated. Imaging changes associated with non-motor complications of PD are presented. The similarities and differences in imaging findings in Lewy body dementia, Parkinson's Disease dementia and Alzheimer's disease are discussed.

Publication metadata

Author(s): Brooks DJ

Publication type: Review

Publication status: Published

Journal: Neurotherapeutics

Year: 2021

Volume: 18

Pages: 753-771

Print publication date: 01/04/2021

Online publication date: 11/01/2021

Acceptance date: 16/12/2020

ISSN (print): 1933-7213

ISSN (electronic): 1878-7479


DOI: 10.1007/s13311-020-00994-4