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Strategies for Enhancing Polyester-Based Materials for Bone Fixation Applications

Lookup NU author(s): Dr Raasti Naseem, Babis Tzivelekis, Dr Matthew German, Dr Piergiorgio Gentile, Dr Ana Ferreira-Duarte, Professor Kenneth Dalgarno

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Abstract

Polyester based materials are an established option for the manufacture of bone fixation devices, with a range of devices in routine clinical use. This paper reviews the approaches researchers have taken to further developing the materials to improve either their mechanical or biological performance. Polymer blending and co-polymerisation, the use of particulate and fibre bio-ceramic materials to make composite materials, and surface modifications have all been studied, with polymer blending and co-polymerisation and particulate composites the approaches which have been adopted commercially, with the primary focus being on influencing the in vivo degradation rate. There are emerging opportunities in terms of novel polymer blends and nano-scale particulate systems in order to further tune bulk properties, and in terms of surface functionalisation to optimise the initial interaction of devices with the implanted environment, offering the potential to further improve the clinical performance of fracture fixation devices.


Publication metadata

Author(s): Naseem R, Tzivelekis C, German MJ, Gentile P, Ferreira-Duarte A, Dalgarno K

Publication type: Article

Publication status: Published

Journal: Molecules

Year: 2021

Volume: 26

Issue: 4

Online publication date: 13/02/2021

Acceptance date: 09/02/2021

Date deposited: 26/07/2021

ISSN (electronic): 1420-3049

Publisher: MDPI

URL: https://doi.org/10.3390/molecules26040992


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