Toggle Main Menu Toggle Search

Open Access padlockePrints

Electronic Cigarettes and Oral Health

Lookup NU author(s): Dr Richard HollidayORCiD, Professor Nicholas JakubovicsORCiD, Dr Ralf KistORCiD, Professor Philip Preshaw



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Novel nicotine products, particularly electronic cigarettes (e-cigarettes), have become increasingly popular over the last decade. E-cigarettes are sometimes regarded as a less harmful alternative to tobacco smoking and there is some evidence of their potential role as a smoking cessation aid. However, there are concerns about their health consequences particularly in users who are not tobacco smokers, and also when used long-term. Given the mode of delivery of these products, there is potential for oral health consequences. Over the last few years there has been an increasing number of studies conducted to explore their oral health effects. In vitro studies have reported a range of cellular effects, but these are much less pronounced than those resulting from exposure to tobacco smoke. Microbiological studies have indicated that e-cigarette users have a distinct microbiome and there is some indication this may be more pathogenic compared to non-users. Evidence of oral health effects from clinical trials is still limited and most studies to date have been small in scale and usually cross-sectional in design. Epidemiological studies highlight concerns over oral dryness, irritation, and gingival diseases. Interpreting data from e-cigarette studies is challenging, given the different populations that have been investigated and the continual emergence of new products. Overall, studies reveal potential oral health harms, underscoring the importance of efforts to reduce use in non-smokers. However, in smokers who are using e-cigarettes as an aid to help them quit, the benefits of quitting tobacco smoking may outweigh any negative oral health impacts of e-cigarette use, particularly in the short term. Future research is needed to understand the clinical significance of some of the biological changes observed by following different cohorts of users longitudinally in carefully designed clinical studies and pragmatic trials supported by high quality in vitro studies.

Publication metadata

Author(s): Holliday R, Chaffee BW, Jakubovics NS, Kist R, Preshaw PM

Publication type: Article

Publication status: Published

Journal: Journal of Dental Research

Year: 2021

Volume: 100

Issue: 9

Pages: 906-913

Print publication date: 01/08/2021

Online publication date: 25/03/2021

Acceptance date: 19/02/2021

Date deposited: 30/03/2021

ISSN (print): 0022-0345

ISSN (electronic): 1544-0591

Publisher: Sage Publications, Inc.


DOI: 10.1177/00220345211002116

PubMed id: 33764176


Altmetrics provided by Altmetric


Funder referenceFunder name