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5-HT2B Receptors in Liver

Lookup NU author(s): Lucy Gee, Professor Fiona OakleyORCiD


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© 2021, Springer Nature Switzerland AG.The liver has many functions, mainly relating to digestion and detoxification, electrolyte/fluid balancing and haemostasis. Hepatic wound healing is a tightly regulated multi-cellular response to liver injury that stimulates a rapid and efficient repair of the damaged tissue, replacement of lost epithelial cells and restoration of the normal liver architecture and function. Fibrosis is the pathological consequence of chronic liver disease and the accumulation of fibrotic scar tissue impairs liver function, ultimately leading to advanced fibrosis/cirrhosis and increased risk of organ failure or developing liver cancer. In this chapter, we will summarize the important role for serotonin through 5-HT2B receptors reported in hepatocyte proliferation, liver regeneration and fibrosis and in liver metabolic diseases and cancers.

Publication metadata

Author(s): Gee L, Oakley F

Publication type: Book Chapter

Publication status: Published

Book Title: Receptors

Year: 2021

Volume: 35

Pages: 247-264

Online publication date: 13/03/2021

Acceptance date: 02/04/2018

Series Title: Part of the The Receptors book series

Publisher: Humana Press Inc.


DOI: 10.1007/978-3-030-55920-5_14

Library holdings: Search Newcastle University Library for this item

ISBN: 9783030559205