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Lookup NU author(s): Professor Tiago OuteiroORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© Copyright © 2021 Medina, González-Lizárraga, Dominguez-Meijide, Ploper, Parrales, Sequeira, Cima-Omori, Zweckstetter, Del Bel, Michel, Outeiro, Raisman-Vozari, Chehín and Socias.Tauopathies are neurodegenerative disorders with increasing incidence and still without cure. The extensive time required for development and approval of novel therapeutics highlights the need for testing and repurposing known safe molecules. Since doxycycline impacts α-synuclein aggregation and toxicity, herein we tested its effect on tau. We found that doxycycline reduces amyloid aggregation of the 2N4R and K18 isoforms of tau protein in a dose-dependent manner. Furthermore, in a cell free system doxycycline also prevents tau seeding and in cell culture reduces toxicity of tau aggregates. Overall, our results expand the spectrum of action of doxycycline against aggregation-prone proteins, opening novel perspectives for its repurposing as a disease-modifying drug for tauopathies.
Author(s): Medina L, Gonzalez-Lizarraga F, Dominguez-Meijide A, Ploper D, Parrales V, Sequeira S, Cima-Omori M-S, Zweckstetter M, Del Bel E, Michel PP, Outeiro TF, Raisman-Vozari R, Chehin R, Socias SB
Publication type: Article
Publication status: Published
Journal: Frontiers in Aging Neuroscience
Online publication date: 22/03/2021
Acceptance date: 22/02/2021
Date deposited: 19/04/2021
ISSN (electronic): 1663-4365
Publisher: Frontiers Media S.A.
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