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The motor basis for misophonia

Lookup NU author(s): Dr Sukhbinder Kumar, Dr Pradeep Dheerendra, Ester Benzaquen Vallejos, Dr Will Sedley, Dr Meher Lad, Professor Tim Griffiths

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Abstract

© 2021 Kumar et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.Misophonia is a common disorder characterized by the experience of strong negative emotions of anger and anxiety in response to certain everyday sounds, such as those generated by other people eating, drinking and breathing. The commonplace nature of these 'trigger' sounds makes misophonia a devastating disorder for sufferers and their families. How such innocuous sounds trigger this response is unknown. Since most trigger sounds are generated by orofacial movements (e.g. chewing) in others, we hypothesized that the mirror neuron system related to orofacial movements could underlie misophonia. We analysed resting state fMRI (rs-fMRI) connectivity (N=33, 16 females) and sound-evoked fMRI responses (N=42, 29 females) in misophonia sufferers and controls. We demonstrate that, compared to controls, the misophonia group show no difference in auditory cortex responses to trigger sounds, but do show: (i) stronger rs-fMRI connectivity between both auditory and visual cortex and the ventral pre-motor cortex responsible for orofacial movements; (ii) stronger functional connectivity between the auditory cortex and orofacial motor area during sound perception in general; (iii) stronger activation of the orofacial motor area, specifically, in response to trigger sounds. Our results support a model of misophonia based on 'hyper-mirroring' of the orofacial actions of others with sounds being the 'medium' via which action of others is excessively mirrored. Misophonia is therefore not an abreaction to sounds, per se, but a manifestation of activity in parts of the motor system involved in producing those sounds. This new framework to understand misophonia can explain behavioural and emotional responses and has important consequences for devising effective therapies.


Publication metadata

Author(s): Kumar S, Dheerendra P, Erfanian M, Benzaquen E, Sedley W, Gander PE, Lad M, Bamiou DE, Griffiths TD

Publication type: Article

Publication status: Published

Journal: Journal of Neuroscience

Year: 2021

Volume: 41

Issue: 26

Pages: 5762–5770

Print publication date: 30/06/2021

Online publication date: 21/05/2021

Acceptance date: 27/04/2021

Date deposited: 10/08/2021

ISSN (print): 0270-6474

ISSN (electronic): 1529-2401

Publisher: Society for Neuroscience

URL: https://doi.org/10.1523/JNEUROSCI.0261-21.2021

DOI: 10.1523/JNEUROSCI.0261-21.2021

PubMed id: 34021042


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