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Molecular features of non-anaplastic peripheral T-cell lymphoma in children and adolescents

Lookup NU author(s): Dr Christopher Bacon

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).

Abstract

© 2021 The Authors. Pediatric Blood & Cancer published by Wiley Periodicals LLCNon-anaplasticperipheral T-cell lymphomas (PTCL) are rare tumors in children, adolescents, and young adults (CAYA) with poor prognosis and scarce genetic data. We analyzed lymphoma tissue from 36 patients up to 18 years old with PTCL, not otherwise specified (PTCL-NOS), hepatosplenic T-cell lymphoma, Epstein–Barr virus (EBV)-positive T-lymphoproliferative diseases, subcutaneous panniculitis-like T-cell lymphoma, and other PTCL types. Twenty-three patients (64%) had at least one genetic variant detectable, including TET2, KMT2C, PIK3D, and DMNT3A. TP53 and RHOA variants, commonly found in adults, were not identified. Eight of 20 (40%) CAYA PTCL-NOS had no detectable mutations. The genetic findings suggest that CAYA PTCL differ from adult cases.

Publication metadata

Author(s): Au-Yeung RKH, Richter J, Iaccarino I, Abramov D, Bacon CM, Balague O, d'Amore ESG, Simonitsch-Klupp I, Hebeda K, Nakazawa A, Oschlies I, Kontny U, Woessmann W, Burkhardt B, Klapper W

Publication type: Article

Publication status: Published

Journal: Pediatric Blood and Cancer

Year: 2021

Volume: 68

Issue: 11

Print publication date: 01/11/2021

Online publication date: 13/08/2021

Acceptance date: 28/07/2021

Date deposited: 31/08/2021

ISSN (print): 1545-5009

ISSN (electronic): 1545-5017

Publisher: John Wiley and Sons Inc

URL: https://doi.org/10.1002/pbc.29285

DOI: 10.1002/pbc.29285

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