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Characterising the allergic profile of children with cystic fibrosis

Lookup NU author(s): Dr Michael GraylingORCiD, Dr Ben ShillitoeORCiD, Dr Malcolm Brodlie, Dr Louise MichaelisORCiD



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


© 2021 The Authors. Immunity, Inflammation and Disease published by John Wiley & Sons Ltd.Background: Cystic fibrosis (CF) is a genetic condition that affects multiple organ systems. Allergic bronchopulmonary aspergillosis (ABPA) is a well-recognised problem but other allergic conditions are less well documented in CF. Objective: To characterise the allergic profile of a cohort of children with CF, with a focus on those with ABPA. Methods: A cohort of children with CF were interviewed and retrospective data were collected regarding their allergic histories and other relevant clinical features. Results: The cohort included 37 children with median age of 9 years (interquartile range: 6-12). There was a history of ≥1 allergic condition(s) in 28/37 children (76%). The most common allergic condition was allergic rhinitis (AR) in 21/37 (57%) and 16 of these 21 children (76%) had another allergic condition. All children with ABPA (8) had another allergic condition. In some children ABPA exacerbations appeared to be seasonal, suggesting possible cross-sensitisation between Aspergillus fumigatus and aeroallergens associated with seasonal AR. Allergic conditions were also common in children with Pseudomonas aeruginosa infection.

Publication metadata

Author(s): Faulkner AL, Grayling M, Shillitoe B, Brodlie M, Michaelis LJ

Publication type: Article

Publication status: Published

Journal: Immunity, Inflammation and Disease

Year: 2022

Volume: 10

Issue: 1

Pages: 60-69

Print publication date: 01/01/2022

Online publication date: 27/09/2021

Acceptance date: 01/09/2021

Date deposited: 07/10/2021

ISSN (electronic): 2050-4527

Publisher: John Wiley and Sons Ltd


DOI: 10.1002/iid3.540


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