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Lookup NU author(s): Dr Michael GraylingORCiD, Dr Ben ShillitoeORCiD, Dr Malcolm Brodlie, Dr Louise MichaelisORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2021 The Authors. Immunity, Inflammation and Disease published by John Wiley & Sons Ltd.Background: Cystic fibrosis (CF) is a genetic condition that affects multiple organ systems. Allergic bronchopulmonary aspergillosis (ABPA) is a well-recognised problem but other allergic conditions are less well documented in CF. Objective: To characterise the allergic profile of a cohort of children with CF, with a focus on those with ABPA. Methods: A cohort of children with CF were interviewed and retrospective data were collected regarding their allergic histories and other relevant clinical features. Results: The cohort included 37 children with median age of 9 years (interquartile range: 6-12). There was a history of ≥1 allergic condition(s) in 28/37 children (76%). The most common allergic condition was allergic rhinitis (AR) in 21/37 (57%) and 16 of these 21 children (76%) had another allergic condition. All children with ABPA (8) had another allergic condition. In some children ABPA exacerbations appeared to be seasonal, suggesting possible cross-sensitisation between Aspergillus fumigatus and aeroallergens associated with seasonal AR. Allergic conditions were also common in children with Pseudomonas aeruginosa infection.
Author(s): Faulkner AL, Grayling M, Shillitoe B, Brodlie M, Michaelis LJ
Publication type: Article
Publication status: Published
Journal: Immunity, Inflammation and Disease
Year: 2022
Volume: 10
Issue: 1
Pages: 60-69
Print publication date: 01/01/2022
Online publication date: 27/09/2021
Acceptance date: 01/09/2021
Date deposited: 07/10/2021
ISSN (electronic): 2050-4527
Publisher: John Wiley and Sons Ltd
URL: https://doi.org/10.1002/iid3.540
DOI: 10.1002/iid3.540
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