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Understanding the Pancreatic Islet Microenvironment in Cystic Fibrosis and the Extrinsic Pathways Leading to Cystic Fibrosis Related Diabetes

Lookup NU author(s): Yara Al-Selwi, Professor James Shaw, Dr Nicole Kattner



This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).


© The Author(s) 2021. Cystic fibrosis (CF) is an autosomal recessive chronic condition effecting approximately 70 000 to 100 000 people globally and is caused by a loss-of-function mutation in the CF transmembrane conductance regulator. Through improvements in clinical care, life expectancy in CF has increased considerably associated with rising incidence of secondary complications including CF-related diabetes (CFRD). CFRD is believed to result from β-cell loss as well as insufficient insulin secretion due to β-cell dysfunction, but the underlying pathophysiology is not yet fully understood. Here we review the morphological and cellular changes in addition to the architectural remodelling of the pancreatic exocrine and endocrine compartments in CF and CFRD pancreas. We consider also potential underlying proinflammatory signalling pathways impacting on endocrine and specifically β-cell function, concluding that further research focused on these mechanisms may uncover novel therapeutic targets enabling restoration of normal insulin secretion.

Publication metadata

Author(s): Al-Selwi Y, Shaw JAM, Kattner N

Publication type: Review

Publication status: Published

Journal: Clinical Medicine Insights: Endocrinology and Diabetes

Year: 2021

Volume: 14

Pages: 1-7

Online publication date: 12/10/2021

Acceptance date: 23/07/2021

ISSN (electronic): 1179-5514

Publisher: SAGE Publications Ltd


DOI: 10.1177/11795514211048813