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Lookup NU author(s): Saad Aldalaqan,
Dr Sara Luzzi,
Dr Louise Reynard,
Dr Ingrid Ehrmann,
Professor David Elliott
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.High levels of transcription and alternative splicing are recognized hallmarks of gene expression in the testis and largely driven by cells in meiosis. Because of this, the male meiosis stage of the cell cycle is often viewed as having a relatively permissive environment for gene expression. In this review, we highlight recent findings that identify the RNA binding protein RBMXL2 as essential for male meiosis. RBMXL2 functions as a “guardian of the transcriptome” that protects against the use of aberrant (or “cryptic”) splice sites that would disrupt gene expression. This newly discovered protective role during meiosis links with a wider field investigating mechanisms of cryptic splicing control that protect neurons from amyotrophic lateral sclerosis and Alzheimer’s disease. We discuss how the mechanism repressing cryptic splicing patterns during meiosis evolved, and why it may be essential for sperm production and male fertility.
Author(s): Aldalaqan S, Dalgliesh C, Luzzi S, Siachisumo C, Reynard LN, Ehrmann I, Elliott DJ
Publication type: Review
Publication status: Published
Journal: Cell Cycle
Online publication date: 20/12/2021
Acceptance date: 30/11/2021
ISSN (print): 1538-4101
ISSN (electronic): 1551-4005
Publisher: Taylor and Francis Ltd.