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Translating osteoarthritis genetics research: challenging times ahead

Lookup NU author(s): Professor John LoughlinORCiD

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Abstract

The ultimate goal of molecular genetic studies of human diseases is to translate the discoveries for patient benefit. For diseases that lack licensed disease modifying therapeutics, such as osteoarthritis (OA), the need is acute. OA is polygenic and affects older individuals, with a recent genome-wide study of over 800,000 individuals adding 52 novel association signals to those already reported on for this common arthritis. Many of the predicted effector genes of these signals encode proteins that are targets of drugs for other indications, highlighting re-purposing opportunities. Here, the potential for OA genetic data to translate is discussed, including whether the developmental origin of OA will limit the application of genetic risk data for disease modification purposes.

Publication metadata

Author(s): Loughlin J

Publication type: Article

Publication status: Published

Journal: Trends in Molecular Medicine

Year: 2022

Volume: 28

Issue: 3

Pages: 176-182

Print publication date: 01/03/2022

Online publication date: 12/01/2022

Acceptance date: 03/01/2022

Date deposited: 17/01/2022

ISSN (print): 1471-4914

ISSN (electronic): 1471-499X

Publisher: Elsevier Ltd. * Trends Journals

URL: https://doi.org/10.1016/j.molmed.2021.12.007

DOI: 10.1016/j.molmed.2021.12.007

ePrints DOI: 10.57711/j897-hy20

PubMed id: 35033441

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