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Inferior Extensions of the Atrioventricular Node

Lookup NU author(s): Professor Bob Anderson



This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).


© RADCLIFFE CARDIOLOGY 2021The pathways for excitation of the atrioventricular node enter either superiorly, as the so-called ‘fast’ pathway, or inferiorly as the ‘slow’ pathway. However, knowledge of the specific anatomical details of these pathways is limited. Most of the experimental studies that established the existence of these pathways were conducted in mammalian hearts, which have subtle differences to human hearts. In this review, the authors summarise their recent experiences investigating human cardiac development, correlating these results with the arrangement of the connections between the atrial myocardium and the compact atrioventricular node as revealed by serial sectioning of adult human hearts. They discuss the contributions made from the atrioventricular canal myocardium, as opposed to the primary ring. Both these rings are incorporated into the atrial vestibules, albeit with the primary ring contributing only to the tricuspid vestibule. The atrial septal cardiomyocytes are relatively late contributors to the nodal inputs. Finally, they relate our findings of human cardiac development to the postnatal arrangement.

Publication metadata

Author(s): Anderson RH, Hikspoors JPJM, Tretter JT, Macias Y, Spicer DE, Lamers WH, Sanchez-Quintana D, Sternick EB

Publication type: Article

Publication status: Published

Journal: Arrhythmia and Electrophysiology Review

Year: 2021

Volume: 10

Issue: 4

Pages: 262-272

Online publication date: 15/12/2021

Acceptance date: 02/09/2021

Date deposited: 07/11/2023

ISSN (print): 2050-3369

ISSN (electronic): 2050-3377

Publisher: Radcliffe Medical Media


DOI: 10.15420/aer.2021.43


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