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Primary Sjögren's syndrome: Longitudinal real-world, observational data on health-related quality of life

Lookup NU author(s): Dr Jessica Tarn, Dr Dennis LendremORCiD, Dr Clare LendremORCiD, Ben Hargreaves, Professor Fai NgORCiD



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


© 2022 The Authors. Journal of Internal Medicine published by John Wiley & Sons Ltd on behalf of Association for Publication of The Journal of Internal Medicine. Introduction: Primary Sjögren's syndrome (pSS) is a chronic inflammatory condition, which presents with symptoms of dryness, pain, fatigue and often symptoms of anxiety and depression. Health-related quality of life (HRQoL) is significantly reduced in pSS and the direct and indirect health costs of pSS are substantial. This study aims to determine how symptom burden, disease activity and demographics associate with HRQoL longitudinally over a median of 24-month follow-up period in pSS. Methods: Longitudinal EuroQoL-5 dimension (EQ-5D)–3L data from the Newcastle pSS cohort (n = 377) were evaluated using a survival analysis strategy. Kaplan–Meier and Cox proportional hazards analysis were performed using baseline Newcastle Sjogren's Stratification Tool (NSST) subgroup, EULAR Sjogren's Syndrome Patient Reported Index (ESSPRI), EULAR Sjogren's Syndrome Disease Activity Index (ESSDAI), disease duration, age and sex as covariates including polypharmacy and comorbidity score, where data were available (n = 191). Results: Of the 377 pSS participants analysed in this study, 16% experienced a decline in HRQoL to a health state comparable to or worse than death. NSST subgroup and ESSPRI score had a significant relationship with time to ‘EQ-5D event’, whereas baseline ESSDAI, age, disease duration and sex did not. Conclusion: In pSS, symptom burden and to a great extent NSST subgroup, rather than systemic disease activity, has a significant relationship with HRQoL longitudinally. Improvements in symptom burden have the potential to produce significant impacts on long-term HRQoL in pSS.

Publication metadata

Author(s): Tarn J, Lendrem D, McMeekin P, Lendrem C, Hargreaves B, Ng W-F

Publication type: Article

Publication status: Published

Journal: Journal of Internal Medicine

Year: 2022

Volume: 291

Issue: 6

Pages: 849-855

Online publication date: 11/01/2022

Acceptance date: 11/01/2022

Date deposited: 09/03/2022

ISSN (print): 0954-6820

ISSN (electronic): 1365-2796

Publisher: John Wiley and Sons Inc.


DOI: 10.1111/joim.13451

PubMed id: 35018685


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Funder referenceFunder name
Foundation for Research in Rheumatology. Grant Number: 022
Medical Research Council. Grant Number: G0800629