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Lookup NU author(s): Dr David Bolam
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© 2022 Elsevier Inc. Humans harbor numerous species of colonic bacteria that digest fiber polysaccharides in commonly consumed terrestrial plants. More recently in history, regional populations have consumed edible macroalgae seaweeds containing unique polysaccharides. It remains unclear how extensively gut bacteria have adapted to digest these nutrients. Here, we show that the ability of gut bacteria to digest seaweed polysaccharides is more pervasive than previously appreciated. Enrichment-cultured Bacteroides harbor previously discovered genes for seaweed degradation, which have mobilized into several members of this genus. Additionally, other examples of marine bacteria-derived genes, and their mobile DNA elements, are involved in gut microbial degradation of seaweed polysaccharides, including genes in gut-resident Firmicutes. Collectively, these results uncover multiple separate events that have mobilized the genes encoding seaweed-degrading-enzymes into gut bacteria. This work further underscores the metabolic plasticity of the human gut microbiome and global exchange of genes in the context of dietary selective pressures.
Author(s): Pudlo NA, Pereira GV, Parnami J, Cid M, Markert S, Tingley JP, Unfried F, Ali A, Varghese NJ, Kim KS, Campbell A, Urs K, Xiao Y, Adams R, Martin D, Bolam DN, Becher D, Eloe-Fadrosh EA, Schmidt TM, Abbott DW, Schweder T, Hehemann JH, Martens EC
Publication type: Article
Publication status: Published
Journal: Cell Host and Microbe
Year: 2022
Volume: 30
Issue: 3
Pages: 314-328.e11
Print publication date: 09/03/2022
Online publication date: 02/03/2022
Acceptance date: 02/02/2022
ISSN (print): 1931-3128
ISSN (electronic): 1934-6069
Publisher: Cell Press
URL: https://doi.org/10.1016/j.chom.2022.02.001
DOI: 10.1016/j.chom.2022.02.001
PubMed id: 35240043
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