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Prospective Studies on the Risk of Rheumatoid Arthritis: The European Risk RA Registry

Lookup NU author(s): Dr Arthur PrattORCiD



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Copyright © 2022 Studenic, Hensvold, Kleyer, van der Helm-van Mil, Pratt, Sieghart, Krönke, Williams, de Souza, Karlfeldt, Johannesson, Krogh, Klareskog and Catrina. Background: The accumulation of risk for the development of rheumatoid arthritis (RA) is regarded as a continuum that may start with interacting environmental and genetic factors, proceed with the initiation of autoimmunity, and result in the formation of autoantibodies such as anti-citrullinated peptide antibodies (ACPA). In parallel, at-risk individuals may be asymptomatic or experience joint pain (arthralgia) that is itself non-specific or clinically suspicious for evolving RA, even in the absence of overt arthritis. Optimal strategies for the management of people at-risk of RA, both for symptom control and to delay or prevent progression to classifiable disease, remain poorly understood. Methods: To help address this, groups of stakeholders from academia, clinical rheumatology, industry and patient research partners have collaborated to advance understanding, define and study different phases of the at-risk state. In this current report we describe different European initiatives in the field and the successful effort to build a European Registry of at-risk people to facilitate observational and interventional research. Results: We outline similarities and differences between cohorts of at-risk individuals at institutions spanning several countries, and how to best combine them within the new database. Over the past 2 years, besides building the technical infrastructure, we have agreed on a core set of variables that all partners should strive to collect for harmonization purposes. Conclusion: We emphasize to address this process from different angles and touch on the biologic, epidemiologic, analytic, and regulatory aspects of collaborative studies within a meta-database of people at-risk of RA.

Publication metadata

Author(s): Studenic P, Hensvold A, Kleyer A, van der Helm-van Mil A, Pratt AG, Sieghart D, Kronke G, Williams R, de Souza S, Karlfeldt S, Johannesson M, Krogh NS, Klareskog L, Catrina AI

Publication type: Article

Publication status: Published

Journal: Frontiers in Medicine

Year: 2022

Volume: 9

Online publication date: 22/02/2022

Acceptance date: 28/01/2022

Date deposited: 22/03/2022

ISSN (electronic): 2296-858X

Publisher: Frontiers Research Foundation


DOI: 10.3389/fmed.2022.824501


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Funder referenceFunder name
777357IMI Joint Undertaking
European Union's Horizon 2020 Research and Innovation Programme
FOREUM research fellowship grant