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Stimulus dependence of directed information exchange between cortical layers in macaque V1

Lookup NU author(s): Dr Alwin GieselmannORCiD, Professor Alexander Thiele



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


© 2022, Gieselmann and Thiele. Perception and cognition require the integration of feedforward sensory information with feedback signals. Using different sized stimuli, we isolate spectral signatures of feedforward and feedback signals, and their effect on communication between layers in primary visual cortex of male macaque monkeys. Small stimuli elicited gamma frequency oscillations predominantly in the superficial layers. These Granger-causally originated in upper layer 4 and lower supragranular layers. Unexpectedly, large stimuli generated strong narrow band gamma oscillatory activity across cortical layers. They Granger-causally arose in layer 5, were conveyed through layer six to superficial layers, and violated existing models of feedback spectral signatures. Equally surprising, with large stimuli, alpha band oscillatory activity arose predominantly in granular and supragranular layers and communicated in a feedforward direction. Thus, oscillations in specific frequency bands are dynamically modulated to serve feedback and feedforward communication and are not restricted to specific cortical layers in V1.

Publication metadata

Author(s): Gieselmann MA, Thiele A

Publication type: Article

Publication status: Published

Journal: eLife

Year: 2022

Volume: 11

Online publication date: 11/03/2022

Acceptance date: 08/02/2022

Date deposited: 28/03/2022

ISSN (electronic): 2050-084X

Publisher: eLife Sciences Publications Ltd


DOI: 10.7554/eLife.62949

PubMed id: 35274614


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Funder referenceFunder name
MR/P013031/1Medical Research Council (MRC)