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Noncoding RNAs in age-related cardiovascular diseases

Lookup NU author(s): Dr Simon Tual-ChalotORCiD, Professor Konstantinos StellosORCiD

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Abstract

© 2022 Elsevier B.V. Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality in the adult population worldwide and represent a severe economic burden and public health concern. The majority of human genes do not code for proteins. However, noncoding transcripts play important roles in ageing that significantly increases the risk for CVDs. Noncoding RNAs (ncRNAs) are critical regulators of multiple biological processes related to ageing such as oxidative stress, mitochondrial dysfunction and chronic inflammation. NcRNAs are also involved in pathophysiological developments within the cardiovascular system including arrhythmias, cardiac hypertrophy, fibrosis, myocardial infarction and heart failure. In this review article, we cover the roles of ncRNAs in cardiovascular ageing and disease as well as their potential therapeutic applications in CVDs.

Publication metadata

Author(s): Jusic A, Thomas PB, Wettinger SB, Dogan S, Farrugia R, Gaetano C, Tuna BG, Pinet F, Robinson EL, Tual-Chalot S, Stellos K, Devaux Y

Publication type: Review

Publication status: Published

Journal: Ageing Research Reviews

Year: 2022

Volume: 77

Print publication date: 01/05/2022

Online publication date: 23/03/2022

Acceptance date: 15/03/2022

ISSN (print): 1568-1637

ISSN (electronic): 1872-9649

Publisher: Elsevier Ireland Ltd

URL: https://doi.org/10.1016/j.arr.2022.101610

DOI: 10.1016/j.arr.2022.101610

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