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Lookup NU author(s): Dr Simon Tual-Chalot, Professor Konstantinos StellosORCiD
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© 2022 Elsevier B.V. Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality in the adult population worldwide and represent a severe economic burden and public health concern. The majority of human genes do not code for proteins. However, noncoding transcripts play important roles in ageing that significantly increases the risk for CVDs. Noncoding RNAs (ncRNAs) are critical regulators of multiple biological processes related to ageing such as oxidative stress, mitochondrial dysfunction and chronic inflammation. NcRNAs are also involved in pathophysiological developments within the cardiovascular system including arrhythmias, cardiac hypertrophy, fibrosis, myocardial infarction and heart failure. In this review article, we cover the roles of ncRNAs in cardiovascular ageing and disease as well as their potential therapeutic applications in CVDs.
Author(s): Jusic A, Thomas PB, Wettinger SB, Dogan S, Farrugia R, Gaetano C, Tuna BG, Pinet F, Robinson EL, Tual-Chalot S, Stellos K, Devaux Y
Publication type: Review
Publication status: Published
Journal: Ageing Research Reviews
Year: 2022
Volume: 77
Print publication date: 01/05/2022
Online publication date: 23/03/2022
Acceptance date: 15/03/2022
ISSN (print): 1568-1637
ISSN (electronic): 1872-9649
Publisher: Elsevier Ireland Ltd
URL: https://doi.org/10.1016/j.arr.2022.101610
DOI: 10.1016/j.arr.2022.101610
