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Lookup NU author(s): Dr Elisa Villalobos VillegasORCiD,
Professor Brian WalkerORCiD
This is the authors' accepted manuscript of a review published in its final definitive form in 2022. For re-use rights please refer to the publishers terms and conditions.
Responses to hormones that act through nuclear receptors are controlled by modulating hormone concentrations not only in the circulation but also within target tissues. The role of enzymes that amplify or reduce local hormone concentrations has become well-established for glucocorticoid and other lipophilic hormones; moreover, transmembrane transporters have proven critical in determining tissue responses to thyroid hormones. However, there has been less consideration of the role of transmembrane transport for steroid hormones. ATP-binding cassette (ABC) proteins were first shown to influence the accumulation of glucocorticoids in cells almost three decades ago, but observations over the past ten years suggest that differential transport propensities of both exogenous and endogenous glucocorticoids by ABCB1 and ABCC1 transporters provides a mechanism whereby different tissues are preferentially sensitive to different steroids. This Review summarises this evidence and the new insights provided for the physiology and pharmacology of glucocorticoid action, including new approaches to glucocorticoid replacement.
Author(s): Devine K, Villalobos E, Kyle CJ, Andrew R, Reynolds RM, Stimson RH, Nixon M, Walker BR
Publication type: Review
Publication status: Published
Journal: Nature Reviews Endocrinology
Online publication date: 11/10/2022
Acceptance date: 23/08/2022
ISSN (print): 1759-5029
ISSN (electronic): 1759-5037
ePrints DOI: 10.57711/3ex1-7208