Browse by author
Lookup NU author(s): Professor Bob Anderson
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2022 The AuthorsBackground: Mitral annular disjunction is the atrial displacement of the mural mitral valve leaflet hinge point within the atrioventricular junction. Said to be associated with malignant ventricular arrhythmias and sudden death, its prevalence in the general population is not known. Objectives: The purpose of this study was to assess the frequency of occurrence and extent of mitral annular disjunction in a large population cohort. Methods: The authors assessed the cardiac magnetic resonance (CMR) images in 2,646 Caucasian subjects enrolled in the UK Biobank imaging study, measuring the length of disjunction at 4 points around the mitral annulus, assessing for presence of prolapse or billowing of the leaflets, and for curling motion of the inferolateral left ventricular wall. Results: From 2,607 included participants, the authors found disjunction in 1,990 (76%) cases, most commonly at the anterior and inferior ventricular wall. The authors found inferolateral disjunction, reported as clinically important, in 134 (5%) cases. Prolapse was more frequent in subjects with disjunction (odds ratio [OR]: 2.5; P = 0.02), with positive associations found between systolic curling and disjunction at any site (OR: 3.6; P < 0.01), and systolic curling and prolapse (OR: 71.9; P < 0.01). Conclusions: This large-scale study shows that disjunction is a common finding when using CMR. Disjunction at the inferolateral ventricular wall, however, was rare. The authors found associations between disjunction and both prolapse and billowing of the mural mitral valve leaflet. These findings support the notion that only extensive inferolateral disjunction, when found, warrants consideration of further investigation, but disjunction elsewhere in the annulus should be considered a normal finding.
Author(s): Zugwitz D, Fung K, Aung N, Rauseo E, McCracken C, Cooper J, El Messaoudi S, Anderson RH, Piechnik SK, Neubauer S, Petersen SE, Nijveldt R
Publication type: Article
Publication status: Published
Journal: JACC: Cardiovascular Imaging
Year: 2022
Volume: 15
Issue: 11
Pages: 1856-1866
Print publication date: 01/11/2022
Online publication date: 19/10/2022
Acceptance date: 13/07/2022
Date deposited: 29/11/2022
ISSN (print): 1936-878X
ISSN (electronic): 1876-7591
Publisher: Elsevier Inc.
URL: https://doi.org/10.1016/j.jcmg.2022.07.015
DOI: 10.1016/j.jcmg.2022.07.015
PubMed id: 36280553
Altmetrics provided by Altmetric
