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Advances in biomimetic collagen mineralisation and future approaches to bone tissue engineering

Lookup NU author(s): Dr Michael Doyle, Professor Kenneth Dalgarno, Dr Enrico Masoero, Dr Ana Ferreira-DuarteORCiD

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Abstract

© 2022 The Authors. Biopolymers published by Wiley Periodicals LLC. With an ageing world population and ~20% of adults in Europe being affected by bone diseases, there is an urgent need to develop advanced regenerative approaches and biomaterials capable to facilitate tissue regeneration while providing an adequate microenvironment for cells to thrive. As the main components of bone are collagen and apatite mineral, scientists in the tissue engineering field have attempted in combining these materials by using different biomimetic approaches to favour bone repair. Still, an ideal bone analogue capable of mimicking the distinct properties (i.e., mechanical properties, degradation rate, porosity, etc.) of cancellous bone is to be developed. This review seeks to sum up the current understanding of bone tissue mineralisation and structure while providing a critical outlook on the existing biomimetic strategies of mineralising collagen for bone tissue engineering applications, highlighting where gaps in knowledge exist.

Publication metadata

Author(s): Doyle ME, Dalgarno K, Masoero E, Ferreira AM

Publication type: Review

Publication status: Published

Journal: Biopolymers

Year: 2023

Volume: 114

Issue: 1

Print publication date: 01/01/2023

Online publication date: 29/11/2022

Acceptance date: 11/11/2022

ISSN (print): 0006-3525

ISSN (electronic): 1097-0282

Publisher: John Wiley and Sons Inc

URL: https://doi.org/10.1002/bip.23527

DOI: 10.1002/bip.23527

PubMed id: 36444710

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