Browse by author
Lookup NU author(s): Dr Michael Doyle, Professor Kenneth Dalgarno, Dr Enrico Masoero, Dr Ana Ferreira-DuarteORCiD
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
© 2022 The Authors. Biopolymers published by Wiley Periodicals LLC.With an ageing world population and ~20% of adults in Europe being affected by bone diseases, there is an urgent need to develop advanced regenerative approaches and biomaterials capable to facilitate tissue regeneration while providing an adequate microenvironment for cells to thrive. As the main components of bone are collagen and apatite mineral, scientists in the tissue engineering field have attempted in combining these materials by using different biomimetic approaches to favour bone repair. Still, an ideal bone analogue capable of mimicking the distinct properties (i.e., mechanical properties, degradation rate, porosity, etc.) of cancellous bone is to be developed. This review seeks to sum up the current understanding of bone tissue mineralisation and structure while providing a critical outlook on the existing biomimetic strategies of mineralising collagen for bone tissue engineering applications, highlighting where gaps in knowledge exist.
Author(s): Doyle ME, Dalgarno K, Masoero E, Ferreira AM
Publication type: Review
Publication status: Published
Journal: Biopolymers
Year: 2022
Pages: epub ahead of print
Online publication date: 29/11/2022
Acceptance date: 11/11/2022
ISSN (print): 0006-3525
ISSN (electronic): 1097-0282
Publisher: John Wiley and Sons Inc
URL: https://doi.org/10.1002/bip.23527
DOI: 10.1002/bip.23527
PubMed id: 36444710
