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The Idiopathic Pulmonary Fibrosis-Associated Single Nucleotide Polymorphism RS35705950 Is Transcribed in a MUC5B Promoter Associated Long Non-Coding RNA (AC061979.1)

Lookup NU author(s): Ruxandra Neatu, Dr Dean Thompson, Dr Ed Schwalbe, Dr Stephany Veuger

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).

Abstract

© 2022 by the authors. LncRNAs are involved in regulatory processes in the human genome, including gene expression. The rs35705950 SNP, previously associated with IPF, overlaps with the recently annotated lncRNA AC061979.1, a 1712 nucleotide transcript located within the MUC5B promoter at chromosome 11p15.5. To document the expression pattern of the transcript, we processed 3.9 TBases of publicly available RNA-SEQ data across 27 independent studies involving lung airway epithelial cells. Epithelial lung cells showed expression of this putative pancRNA. The findings were independently validated in cell lines and primary cells. The rs35705950 is found within a conserved region (from fish to primates) within the expressed sequence indicating functional importance. These results implicate the rs35705950-containing AC061979.1 pancRNA as a novel component of the MUC5B expression control minicircuitry.

Publication metadata

Author(s): Neatu R, Enekwa I, Thompson DJ, Schwalbe EC, Fois G, Abdelaal G, Veuger S, Frick M, Braubach P, Moschos SA

Publication type: Article

Publication status: Published

Journal: Non-Coding RNA

Year: 2022

Volume: 8

Issue: 6

Online publication date: 08/12/2022

Acceptance date: 30/11/2022

Date deposited: 10/01/2023

ISSN (electronic): 2311-553X

Publisher: MDPI

URL: https://doi.org/10.3390/ncrna8060083

DOI: 10.3390/ncrna8060083

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