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Lookup NU author(s): Dr Sarah Upson, Dr Matthew Benning, Professor David Fulton, Dr Ian Corbett, Professor Kenneth Dalgarno, Dr Matthew GermanORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2023 by the authors.Bone adhesives offer distinct advantages over the use of screws to attached internal fixation plates (IFPs). As the chemical composition of bone is similar to dentine, it is possible that the types of monomers used to make dentine adhesives could be utilised to affix IFPs to bone. The ability to attach a bio-resorbable IFP to porcine bone was assessed for the monomer 10-methacryloyloxydecyl dihydrogen phosphate (MDP), used either as a homopolymer or a copolymer with urethane dimethacrylate (MDP + U). Additionally, the addition of a priming step (MDP + U + P) was evaluated. The chemical interactions of the monomers with bone were assessed using XRD and imaged using TEM, revealing the formation of nano-layered structures with the MDP primer, something we believe has not been reported on bone. In a 6-week artificial aging study both MDP + U and MDP + U + P demonstrated adequate shear bond strength to affix bio-resorbable IFPs. The cytotoxicity profiles of the adhesive formulations were determined using indirect and direct contact with MC3T3 cells, with indirect conditions suggesting the MDP + U + P is as cytocompatible as the resorbable IFP. The findings of this study suggest our newly developed adhesive has the potential to be used as a bone adhesive to affix bioresorbable IFPs.
Author(s): Upson SJ, Benning MJ, Fulton DA, Corbett IP, Dalgarno KW, German MJ
Publication type: Article
Publication status: Published
Journal: Bioengineering
Year: 2023
Volume: 10
Issue: 1
Print publication date: 01/01/2023
Online publication date: 06/01/2023
Acceptance date: 23/12/2022
Date deposited: 07/02/2023
ISSN (electronic): 2306-5354
Publisher: MDPI
URL: https://doi.org/10.3390/bioengineering10010078
DOI: 10.3390/bioengineering10010078
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