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Lookup NU author(s): Jafar Doostmohammadi, Dr Alwin GieselmannORCiD, Dr Jochem van KempenORCiD, Professor Alexander Thiele
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Sharp-wave ripples (SWRs) are highly synchronous neuronal activity events. They have been predominantly observed in the hippocampus during offline states such as pause in exploration, slow-wave sleep, and quiescent wakefulness. SWRs have been linked to memory consolidation, spatial navigation, and spatial decision-making. Recently, SWRs have been reported during visual search, a form of remote spatial exploration, in macaque hippocampus. However, the association between SWRs and multiple forms of awake conscious and goal-directed behavior is unknown. We report that ripple activity occurs in macaque visual areas V1 and V4 during focused spatial attention. The occurrence of ripples is modulated by stimulus characteristics, increased by attention toward the receptive field, and by the size of the attentional focus. During attention cued to the receptive field, the monkey's reaction time in detecting behaviorally relevant events was reduced by ripples. These results show that ripple activity is not limited to hippocampal activity during offline states, rather they occur in the neocortex during active attentive states and vigilance behaviors.
Author(s): Doostmohammadi J, Gieselmann MA, van Kempen J, Lashgari R, Yoonessi A, Thiele A
Publication type: Article
Publication status: Published
Journal: Proceedings of the National Academy of Sciences of the United States of America
Year: 2023
Volume: 120
Issue: 5
Print publication date: 31/01/2023
Online publication date: 25/01/2023
Acceptance date: 22/11/2022
Date deposited: 09/02/2023
ISSN (print): 0027-8424
ISSN (electronic): 1091-6490
Publisher: National Academy of Sciences
URL: https://doi.org/10.1073/pnas.2210698120
DOI: 10.1073/pnas.2210698120
PubMed id: 36696442
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