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Ripples in macaque V1 and V4 are modulated by top-down visual attention

Lookup NU author(s): Jafar Doostmohammadi, Dr Alwin GieselmannORCiD, Dr Jochem van KempenORCiD, Professor Alexander Thiele



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Sharp-wave ripples (SWRs) are highly synchronous neuronal activity events. They have been predominantly observed in the hippocampus during offline states such as pause in exploration, slow-wave sleep, and quiescent wakefulness. SWRs have been linked to memory consolidation, spatial navigation, and spatial decision-making. Recently, SWRs have been reported during visual search, a form of remote spatial exploration, in macaque hippocampus. However, the association between SWRs and multiple forms of awake conscious and goal-directed behavior is unknown. We report that ripple activity occurs in macaque visual areas V1 and V4 during focused spatial attention. The occurrence of ripples is modulated by stimulus characteristics, increased by attention toward the receptive field, and by the size of the attentional focus. During attention cued to the receptive field, the monkey's reaction time in detecting behaviorally relevant events was reduced by ripples. These results show that ripple activity is not limited to hippocampal activity during offline states, rather they occur in the neocortex during active attentive states and vigilance behaviors.

Publication metadata

Author(s): Doostmohammadi J, Gieselmann MA, van Kempen J, Lashgari R, Yoonessi A, Thiele A

Publication type: Article

Publication status: Published

Journal: Proceedings of the National Academy of Sciences of the United States of America

Year: 2023

Volume: 120

Issue: 5

Print publication date: 31/01/2023

Online publication date: 25/01/2023

Acceptance date: 22/11/2022

Date deposited: 09/02/2023

ISSN (print): 0027-8424

ISSN (electronic): 1091-6490

Publisher: National Academy of Sciences


DOI: 10.1073/pnas.2210698120

PubMed id: 36696442


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Funder referenceFunder name
093104Wellcome Trust
MR/P013031/1Medical Research Council (MRC)
MR/K013785/1Medical Research Council (MRC)