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Lookup NU author(s): Dr Alwin GieselmannORCiD, Professor Alexander Thiele
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2023. The Author(s).Intrinsic timescales characterize dynamics of endogenous fluctuations in neural activity. Variation of intrinsic timescales across the neocortex reflects functional specialization of cortical areas, but less is known about how intrinsic timescales change during cognitive tasks. We measured intrinsic timescales of local spiking activity within columns of area V4 in male monkeys performing spatial attention tasks. The ongoing spiking activity unfolded across at least two distinct timescales, fast and slow. The slow timescale increased when monkeys attended to the receptive fields location and correlated with reaction times. By evaluating predictions of several network models, we found that spatiotemporal correlations in V4 activity were best explained by the model in which multiple timescales arise from recurrent interactions shaped by spatially arranged connectivity, and attentional modulation of timescales results from an increase in the efficacy of recurrent interactions. Our results suggest that multiple timescales may arise from the spatial connectivity in the visual cortex and flexibly change with the cognitive state due to dynamic effective interactions between neurons.
Author(s): Zeraati R, Shi Y-L, Steinmetz NA, Gieselmann MA, Thiele A, Moore T, Levina A, Engel TA
Publication type: Article
Publication status: Published
Journal: Nature Communications
Year: 2023
Volume: 14
Issue: 1
Online publication date: 03/04/2023
Acceptance date: 24/03/2023
Date deposited: 28/04/2023
ISSN (electronic): 2041-1723
Publisher: Nature Publishing Group
URL: https://doi.org/10.1038/s41467-023-37613-7
DOI: 10.1038/s41467-023-37613-7
PubMed id: 37012299
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