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Lookup NU author(s): Dr Luke Milross, Dr Joaquim Majo, Bethany Hunter, Professor Andrew FilbyORCiD, Professor Andrew FisherORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY. Published by BMJ.Diffuse alveolar damage (DAD) is the histological expression of acute respiratory distress syndrome and characterises lung pathology due to infection with SARS-CoV-2, and other respiratory pathogens of clinical significance. DAD reflects a time-dependent immunopathological process, progressing from an early/exudative stage through to an organising/fibrotic stage, yet within an individual these different stages of DAD may coexist. Understanding the progression of DAD is central to the development of new therapeutics to limit progressive lung damage. Here, we applied highly multiplexed spatial protein profiling to autopsy lung tissues derived from 27 patients who died from COVID-19 and identified a protein signature (ARG1, CD127, GZMB, IDO1, Ki67, phospho-PRAS40 (T246) and VISTA) that distinguishes early DAD from late DAD with good predictive accuracy. These proteins warrant further investigation as potential regulators of DAD progression.
Author(s): Ashwin H, Milross L, Wilson J, Majo J, Hang Lee JT, Calder G, Hunter B, James S, Lagos D, Signoret N, Filby A, Bayraktar OA, Fisher AJ, Kaye PM
Publication type: Article
Publication status: Published
Journal: Journal of Clinical Pathology
Year: 2023
Volume: 76
Issue: 8
Pages: 561-565
Online publication date: 09/03/2023
Acceptance date: 09/02/2023
Date deposited: 03/05/2023
ISSN (print): 0021-9746
ISSN (electronic): 1472-4146
Publisher: BMJ Publishing Group
URL: https://doi.org/10.1136/jcp-2023-208771
DOI: 10.1136/jcp-2023-208771
PubMed id: 36894313
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