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Lookup NU author(s): Dr Jason Woodgate, Professor Nikolay ZenkinORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2023 The Authors. Molecular Microbiology published by John Wiley & Sons Ltd.The flow of genetic information from the chromosome to protein in all living organisms consists of two steps: (1) copying information coded in DNA into an mRNA intermediate via transcription by RNA polymerase, followed by (2) translation of this mRNA into a polypeptide by the ribosome. Unlike eukaryotes, where transcription and translation are separated by a nuclear envelope, in bacterial cells, these two processes occur within the same compartment. This means that a pioneering ribosome starts translation on nascent mRNA that is still being actively transcribed by RNA polymerase. This tethering via mRNA is referred to as ‘coupling’ of transcription and translation (CTT). CTT raises many questions regarding physical interactions and potential mutual regulation between these large (ribosome is ~2.5 MDa and RNA polymerase is 0.5 MDa) and powerful molecular machines. Accordingly, we will discuss some recently discovered structural and functional aspects of CTT.
Author(s): Woodgate J, Zenkin N
Publication type: Article
Publication status: Published
Journal: Molecular Microbiology
Year: 2023
Volume: 120
Issue: 4
Pages: 539-546
Print publication date: 01/10/2023
Online publication date: 15/05/2023
Acceptance date: 05/05/2023
Date deposited: 01/06/2023
ISSN (print): 0950-382X
ISSN (electronic): 1365-2958
Publisher: John Wiley and Sons Inc
URL: https://doi.org/10.1111/mmi.15076
DOI: 10.1111/mmi.15076
Data Access Statement: Data sharing is not applicable to this article as no new data were created or analyzed in this study.
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