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Discovery and biosynthetic assessment of 'Streptomyces ortus' sp. nov. isolated from a deep-sea sponge

Lookup NU author(s): Dr James StachORCiD, Professor Paul RaceORCiD



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


© 2023 The Authors.The deep sea is known to host novel bacteria with the potential to produce a diverse array of undiscovered natural products. Thus, understanding these bacteria is of broad interest in ecology and could also underpin applied drug discovery, specifically in the area of antimicrobials. Here, we isolate a new strain of Streptomyces from the tissue of the deep-sea sponge Polymastia corticata collected at a depth of 1869 m from the Gramberg Seamount in the Atlantic Ocean. This strain, which was given the initial designation A15ISP2-DRY2T, has a genome size of 9.29 Mb with a G+C content of 70.83 mol%. Phylogenomics determined that A15ISP2-DRY2T represents a novel species within the genus Streptomyces as part of the Streptomyces aurantiacus clade. The biosynthetic potential of A15ISP2-DRY2T was assessed relative to other members of the S. aurantiacus clade via comparative gene cluster family (GCF) analysis. This revealed a clear congruent relationship between phylogeny and GCF content. A15ISP2-DRY2T contains six unique GCFs absent elsewhere in the clade. Culture-based assays were used to demonstrate the antibacterial activity of A15ISP2-DRY2T against two drug-resistant human pathogens. Thus, we determine A15ISP2-DRY2T to be a novel bacterial species with considerable biosynthetic potential and propose the systematic name 'Streptomyces ortus' sp. nov.

Publication metadata

Author(s): Williams SE, Back CR, Best E, Mantell J, Stach JEM, Williams TA, Race PR, Curnow P

Publication type: Article

Publication status: Published

Journal: Microbial Genomics

Year: 2023

Volume: 9

Issue: 5

Online publication date: 11/05/2023

Acceptance date: 23/02/2023

Date deposited: 06/06/2023

ISSN (electronic): 2057-5858

Publisher: Microbiology Society


DOI: 10.1099/mgen.0.000996

PubMed id: 37166955


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Funder referenceFunder name
Elizabeth Blackwell Institute
European Research Council (ERC
MRF-131- 0005- RG-RACE- C085
Wellcome Trust