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Lookup NU author(s): Dr James StachORCiD, Professor Paul RaceORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2023 The Authors.The deep sea is known to host novel bacteria with the potential to produce a diverse array of undiscovered natural products. Thus, understanding these bacteria is of broad interest in ecology and could also underpin applied drug discovery, specifically in the area of antimicrobials. Here, we isolate a new strain of Streptomyces from the tissue of the deep-sea sponge Polymastia corticata collected at a depth of 1869 m from the Gramberg Seamount in the Atlantic Ocean. This strain, which was given the initial designation A15ISP2-DRY2T, has a genome size of 9.29 Mb with a G+C content of 70.83 mol%. Phylogenomics determined that A15ISP2-DRY2T represents a novel species within the genus Streptomyces as part of the Streptomyces aurantiacus clade. The biosynthetic potential of A15ISP2-DRY2T was assessed relative to other members of the S. aurantiacus clade via comparative gene cluster family (GCF) analysis. This revealed a clear congruent relationship between phylogeny and GCF content. A15ISP2-DRY2T contains six unique GCFs absent elsewhere in the clade. Culture-based assays were used to demonstrate the antibacterial activity of A15ISP2-DRY2T against two drug-resistant human pathogens. Thus, we determine A15ISP2-DRY2T to be a novel bacterial species with considerable biosynthetic potential and propose the systematic name 'Streptomyces ortus' sp. nov.
Author(s): Williams SE, Back CR, Best E, Mantell J, Stach JEM, Williams TA, Race PR, Curnow P
Publication type: Article
Publication status: Published
Journal: Microbial Genomics
Year: 2023
Volume: 9
Issue: 5
Online publication date: 11/05/2023
Acceptance date: 23/02/2023
Date deposited: 06/06/2023
ISSN (electronic): 2057-5858
Publisher: Microbiology Society
URL: https://doi.org/10.1099/mgen.0.000996
DOI: 10.1099/mgen.0.000996
PubMed id: 37166955
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