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Moderate doses of dietary nitrate elicit greater effects on blood pressure and endothelial function than a high dose: A 13-week pilot study

Lookup NU author(s): Dr Oliver Shannon, Dr Gerry O'BrienORCiD, Dilara Olgacer, William Fostier, Professor John Mathers, Dr Mario Siervo


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Background & aimsFew studies have explored the prolonged effects of dietary nitrate on vascular health. This pilot study tested the effects of prolonged consumption (13 weeks) of a range of doses of dietary nitrate (NO3), provided as beetroot juice (BJ), on blood pressure (BP) and endothelial function in overweight and obese older participants.Methods and resultsSixty-two overweight or obese older participants (60–75 years) were randomized to the following interventions: (1) high NO3 (2) medium NO3, (3) low NO3, or (4) placebo. Resting clinic and home BP were measured pre- and post-intervention. Laser Doppler iontophoresis was used to quantify changes in endothelial-dependent and independent microvascular blood flow.ResultsThis pilot study showed that medium and low doses of NO3 were more effective in lowering resting-clinic SBP (P = 0.04 and, P = 0.03, respectively) than was PL. The lower doses of NO3 also resulted in significant increases in microvascular perfusion (medium, P = 0.02; low, P = 0.002) relative to baseline values.ConclusionThese findings indicate that supplementation with medium and low, but not high, doses of NO3 for 13 weeks had positive effects on BP and endothelial function in older overweight and obese adults. These findings require confirmation in larger studies

Publication metadata

Author(s): Babateen AM, Shannon OM, O'Brien GM, Olgacer D, Koehl C, Fostier W, Mathers JC, Siervo M

Publication type: Article

Publication status: Published

Journal: Nutrition, Metabolism and Cardiovascular Diseases

Year: 2023

Volume: 33

Issue: 6

Pages: 1263-1267

Print publication date: 13/03/2023

Online publication date: 02/03/2023

Acceptance date: 27/02/2023

ISSN (print): 0939-4753

ISSN (electronic): 1590-3729

Publisher: Elsevier


DOI: 10.1016/j.numecd.2023.02.024


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