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Cystatin C is glucocorticoid responsive, directs recruitment of Trem2+ macrophages, and predicts failure of cancer immunotherapy

Lookup NU author(s): Professor Brian WalkerORCiD

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Author(s): Kleeman SO, Demestichas B, Mourakis N, Loiero D, Ferrer M, Bankier S, Yosef JRA, Lee H, Chantzichristos D, Regan C, Preall J, Sinha S, Rosin N, Yipp B, de Almeida LGN, Biernaskie J, Dufour A, Tober-Lau P, Ruusalepp A, Bjorkegren JLM, Ralser M, Kurth F, Demechev V, Heywood T, Qing G, Johannsson G, Koelzer VH, Walker BR, Meyer HV, Janowitz T

Publication type: Article

Publication status: Published

Journal: Cell Genomics

Year: 2023

Volume: 3

Issue: 8

Print publication date: 09/08/2023

Online publication date: 23/06/2023

Acceptance date: 30/05/2023

Date deposited: 16/08/2023

ISSN (electronic): 2666-979X

Publisher: Cell Press

URL: https://doi.org/10.1016/j.xgen.2023.100347

DOI: 10.1016/j.xgen.2023.100347

Data Access Statement: Due to the data use agreements for the datasets analyzed in this manuscript, we are unable to directly share or distribute any patient-level data except for COVID-19 patient scRNA-seq at https://doi.org/10.6084/m9.figshare.14330795.v13, filename ‘covid.combined final.CD14.Mono.Robj’). GWAS summary statistics are published alongside the study (polygenic scores are deposited in PGS Catalog https://doi.org/10.1101/2021.08.17.21261668. To facilitate dataset requests from applicable data use committees, we provide all accession codes for all datasets relating to this manuscript in the key resources table and in Table S2A. UK Biobank data can be requested through the application process https://www. ukbiobank.ac.uk/. Single-cell RNA sequencing raw sequencing data (FASTQ) is reposited in the Sequence Read Archive (SRA) under BioProject PRJNA961746, while the processed Seurat matrix is available from Figshare (https://doi.org/10.6084/m9.figshare.20063402).


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Funding

Funder referenceFunder name
031L0220A
"La Caixa" Foundation
100010434
161L0221
20-028-EDV
2015-02561
107049/Z/15/Z
58391101
2019-01112
CSHL
Mark Foundation
Ministry of Education and Research (BMBF)
LCF/BQ/AA18/11680037
MRC
Nancy Gay Foundation
Simons Center for Quantitative Biology
Starr Centennial Scholarship
Swedish Research Council
S10OD028632-01
Simons Foundation
Wellcome Trust
US National Institutes of Health

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